Izinyathelo Zokuqapha Nezidingo Zenqubo Ye-Gelatin Kuma-Capsule Aqinile Nathambile

Njengezinto eziyinhloko zokwakha ifilimu ze-hard and i-capsule ethambiles, i-gelatin idinga ikhwalithi eqinile kanye nokulawulwa kwenqubo ukuqinisekisa ukuqina kwe-capsule kanye nokuphepha kwemithi.

Izinyathelo Zokuqapha Zokusebenzisa

1. Ukulawula Ubumsulwa: Khetha i-gelatin yezinga lemithi ukuze ugweme izinsimbi ezisindayo ngokweqile (isb., umthofu, i-mercury) kanye nama-microorganisms, ukuvimbela ukuwohloka kwe-capsule noma izingozi zokuphepha.
2. Ukuphathwa Komswakama: I-Gelatin i-hygroscopic kakhulu. Umswakama wendawo yokugcina kufanele ugcinwe ku-45%-65% ukuze kugwenywe ukuthamba kwe-capsule, ukunamathela, ukuphuka, noma ukuqhekeka. Umswakama we-workshop ngesikhathi sokukhiqiza nawo udinga ukulawulwa ukuqinisekisa ikhwalithi yokubumba.
3. Ukuhambisana Nokuqukethwe: Yenza izivivinyo zokuhambisana kusenesikhathi. Ama-asidi aqinile, ama-alkali, noma izingxenye ezikhipha i-oxidizing kokuqukethwe zingalimaza isakhiwo se-gelatin.

Izidingo Zenqubo

• Ama-Capsule Aqinile: Lawula ngokunembile ukuhlushwa kwesisombululo se-gelatin (ngokuvamile 12%-15%) kanye nokushisa (50-60℃) ukuqinisekisa ukufana ngaphandle kwamabhamuza, ugcine ukujiya kwegobolondo le-capsule okulinganayo (ngokuvamile 0.15-0.25mm). Yomisa amahora angama-24-48 ngemva kokubumba, bese okuqukethwe komswakama kokugcina kuzinziswa ku-12%-16%.
• Amakapsuli Athambile: Faka ama-plasticizer (isb., i-glycerol) esixazululweni se-gelatin ngesilinganiso se-gelatin:glycerol = 1:0.3-0.5 ukuze uthuthukise ukuguquguquka. Lawula izinga lokushisa lokufaka ama-pellet ku-20-30℃ ukuze uvimbele ukuguquka. Yomisa amahora angu-48-72, bese okuqukethwe komswakama kugcinwe ku-12%-16% ukuze kugcinwe kahle.

Kukhona umehluko omkhulu okhona ohlotsheni lwe-gelatin, imininingwane, kanye nezidingo zekhwalithi phakathi kwe-soft kanye ne- i-capsule eqiniles, okuvela ezinqubweni zabo zokukhiqiza ezihlukile kanye nezidingo zesimo somzimba.

1. Umehluko Ohlotsheni Lwe-Gelatin

Nakuba zifana ngamakhemikhali, izakhiwo zomzimba ze-gelatin—ezinqunywa imithombo yezinto zokusetshenziswa kanye nokucutshungulwa kwazo—zenza zifanelekele izinhlobo ezahlukene zama-capsule.

• Ama-Capsule Aqinile: Beka phambili "ubulukhuni" kanye "nokuqina". I-Bone gelatin isetshenziswa kabanzi ngenxa yamandla ayo aphezulu ejeli.
• Amakapsuli Athambile: Beka phambili "ukunwebeka" kanye "nekhono lokwenza ifilimu". I-gelatin yesikhumba (isb., isikhumba sezinkomo, i-gelatin yesikhumba sengulube) ihlangabezana nezidingo zokukhiqiza nge-viscosity efanele kanye ne-plasticity, okunciphisa ukuguquguquka noma ukuqhekeka.

1. Umehluko Ezicacisweni zeGelatin

Amapharamitha abalulekile (amandla ejeli, i-viscosity, umswakama) athinta ngqo ukuzivumelanisa nezimo kwenqubo:

1. I-Gelatin Yama-Capsule Aqinile

• Amandla ejeli: Inkomba eyinhloko, edinga ≥220 I-Bloom g. Amandla aphezulu ejeli aqinisekisa ubulukhuni obungcono kanye nokumelana nokushayisana, okuvimbela ukuphuka.
• Ukuthamba: Kulawulwa ku-25-40 mPa・s (ku-60℃). Ukuthamba okumaphakathi kugwema amagobolondo amancane, aqhekekayo (aphansi kakhulu) noma ukusebenza kahle kokubumba okuncishisiwe (okuphezulu kakhulu).
• Umswakama: ≤12%. Umswakama owedlulele ubangela ukuthamba/ukunamathela; umswakama onganele uholela ekuqhekekeni.

2. I-Gelatin ye Amakapsuli Athambile

• Amandla ejeli: Isidingo esiphansi, ngokuvamile ≥180 Iqhakaza g. Ubulukhuni obuphezulu abudingeki; ukunwebeka kubhekwa njengento ebaluleke kakhulu—amandla ejeli amaningi abangela amagobolondo aqinile naqhekekayo.
• Ukuthamba: Imfuneko ephezulu, 40-60 mPa・s (ku-60℃). I-viscosity ephezulu iqinisekisa ukwakheka kwefilimu okufanayo kanye nokugcinwa kwesimo ngemuva kokubumba.
• Umswakama: ≤13%. Iphakeme kancane kunezikhonkwane eziqinile ukuze igcine ukuqina kwayo kuqinile futhi ivimbele ukuqhekeka okomile.

1. Izidingo Zekhwalithi Ejwayelekile (Izindinganiso Zemithi)

Zombili izinhlobo zama-capsule zidinga i-gelatin yezinga lemithi ehlangabezana nezindlela zokuphepha ezilandelayo kanye nokusebenza kwazo:

1. Ubumsulwa: Ayinazo izinsimbi ezisindayo ngokweqile (isb., i-lead ≤0.1 mg/kg, i-arsenic ≤0.05 mg/kg), ama-microorganism (ahambisana nezindinganiso zomkhawulo we-sterility/microbial, isb., akukho Escherichia coli etholakele), kanye nokungcola okuyingozi.
2. Ukucaca Nombala: Ayinambala noma iphuzi elikhanyayo, ayinawo amafu noma izinto zangaphandle ezicacile, okuqinisekisa ukubukeka okuhlanzekile nokulinganayo.
3. Inani le-pH: 5.5-7.5 (cishe ingathathi hlangothi) ukugwema ukusabela kwe-acid-base nokuqukethwe, okuvikela ukuqina kwesidakamizwa.
4. Okuqukethwe Komlotha: ≤2.0%, okubonisa ubumsulwa—umlotha owedlulele ubonisa ukungcola okungenazo izinto eziphilayo.
5. Ukuncibilika: Iyavuvukala futhi incibilike kancane emanzini, incibilike ngokushesha oketshezini lwesisu ukuqinisekisa ukusebenza kahle kokukhishwa kokuqukethwe.