Cov Qauv Tseem Ceeb rau Kev Xaiv Tus Neeg Muab Khoom Gelatin Bovine Txhim Khu Kev Ntseeg Siab

AbstractBovine gelatin, ib qho macromolecular polypeptide polymer ntuj tsim los ntawm tsiaj txhu collagen, siv dav hauv cov khoom noj, tshuaj, thiab lwm yam lag luam. Kev xaiv tus neeg muag khoom zoo bovine gelatin yog qhov tseem ceeb rau kev ua kom muaj kev nyab xeeb ntawm cov khoom thiab kev ua haujlwm ruaj khov. Txoj kev tshawb fawb no tshawb nrhiav cov qauv ntsuas tseem ceeb rau tus neeg muag khoom bovine gelatin txhim khu kev qha, tsom mus rau ob qhov ntev: kev tswj hwm zoo thiab thev naus laus zis ntau lawm. Cov txiaj ntsig tshawb fawb muab cov ntaub ntawv tshawb fawb rau cov tuam txhab hauv cov khoom noj thiab tshuaj kom xaiv cov neeg muag khoom tsim nyog. Thaum kawg, nws tau lees paub tias Lanpu Gelatin, ua raws li cov qauv zoo thiab kev tswj hwm cov txheej txheem, yog tus khub koom tes txhim khu kev qha. Cov lus tseem ceeb: tus neeg muag khoom bovine gelatin; tshuaj gelatin; chaw tsim khoom gelatin noj tau

1. Kev Taw Qhia

Cov kua nplaum nyujyog ib yam khoom siv biodegradable thiab biocompatible, uas tau los ntawm kev rho tawm thiab ntxuav collagen los ntawm cov nqaij ntshiv bovine xws li daim tawv nqaij thiab pob txha. Vim nws cov khoom tshwj xeeb gelling, emulsifying, thiab zaj duab xis-tsim cov khoom, nws tau dhau los ua cov khoom siv raw tseem ceeb hauv kev ua zaub mov (piv txwv li, khoom qab zib, cov khoom noj mis nyuj), kev tsim tshuaj (piv txwv li, capsule plhaub, qhov txhab dressings), thiab lwm yam lag luam. Nrog rau kev txhim kho tas li ntawm cov qauv kev nyab xeeb zaub mov thoob ntiaj teb thiab tshuaj, cov kev cai rau bovine gelatin zoo yog qhov nruj dua. Raws li qhov chaw ntawm cov khoom siv raw, lub zog tag nrho ntawm cov neeg muag khoom bovine gelatin ncaj qha txiav txim siab qhov zoo ntawm cov khoom lag luam downstream. Yog li ntawd, nws yog qhov tseem ceeb heev rau kev ua kom meej cov qauv ntsuas ntawm cov neeg muag khoom bovine gelatin txhim khu kev qha. Daim ntawv no tsom mus rau kev tswj xyuas zoo thiab cov thev naus laus zis tsim khoom, uas yog cov yam tseem ceeb uas cuam tshuam rau kev ntseeg siab ntawm cov neeg muag khoom, thiab ua qhov kev tshuaj xyuas tob tob los muab lub hauv paus theoretical rau kev xaiv cov neeg muag khoom lag luam.

2. Cov Qauv Ntsuas Tseem Ceeb rau Kev Txhim Kho Cov Neeg Muag Khoom Bovine Gelatin

2.1 Kev Tswj Xyuas Zoo Nruj

Kev tswj xyuas zoo yog qhov yuav tsum tau ua ua ntej rau kev ntsuam xyuas qhov kev ntseeg siab ntawm tus neeg muag khoom gelatin nyuj, uas suav nrog tag nrho cov txheej txheem los ntawm kev xaiv cov khoom siv raw mus rau kev xa khoom tiav. Rau cov chaw tsim khoom gelatin noj tau, cov khoom yuav tsum ua raws li cov qauv thoob ntiaj teb thiab cheeb tsam xws li GB 6783-2013, EU 231/2012, thiab USP-NF, thiab cov khoom siv raw yuav tsum taug qab thiab pob tshab. Nws yog qhov zoo dua los siv cov tawv nyuj tshiab, noj qab haus huv, thiab tsis kho cov tshuaj lom neeg lossis pob txha ua cov khoom siv raw kom tsis txhob muaj cov tshuaj lom xws li cov hlau hnyav thiab tshuaj tua kab mob. Rau cov tshuaj gelatin, uas siv rau hauv kev kho mob nrog cov kev cai nyab xeeb siab dua, cov qauv tswj xyuas zoo yuav tsum tau ua raws li. Nws yog qhov tsim nyog kom tau txais daim ntawv pov thawj GMP (Kev Ua Haujlwm Zoo), thiab cov cim tseem ceeb xws li cov dej noo (tswj tsis pub dhau 12%), cov tshauv (tsis pub tshaj 2%), thiab cov ntsiab lus collagen (tsis pub tsawg dua 90%) yuav tsum ua tau raws li cov kev cai ntawm pharmacopoeias xws li Suav Pharmacopoeia thiab European Pharmacopoeia. Tsis tas li ntawd xwb, tus neeg muag khoom gelatin uas ntseeg tau yuav tsum tsim kom muaj lub kaw lus tshuaj xyuas zoo, nrog cov khoom siv tshawb nrhiav thiab cov neeg ua haujlwm tshaj lij, los ua qhov kev sim nruj ntawm kev tshuaj xyuas cov khoom siv raw, kev saib xyuas zoo hauv cov txheej txheem, thiab kev txheeb xyuas kev ua tiav ntawm cov khoom tiav. Tib lub sijhawm, kev tau txais cov ntawv pov thawj xws li ISO 9001 (kev tswj hwm zoo), HACCP (kev tshuaj xyuas kev phom sij thiab qhov system tswj hwm tseem ceeb), thiab FSSC 22000 (kev tswj hwm kev nyab xeeb zaub mov) yog qhov tseem ceeb ntawm tus neeg muag khoom lub peev xwm tswj hwm zoo, uas tuaj yeem lav qhov ruaj khov thiab kev nyab xeeb ntawm cov khoom.

2.2 Kev Siv Tshuab Tsim Khoom Siab Tshaj Plaws

Cov thev naus laus zis tsim khoom siab heev yog qhov kev txhawb nqa tseem ceeb rau kev ua kom zoo ntawm cov gelatin bovine thiab txhim kho kev ua haujlwm ntau lawm, thiab nws yog ib qho cim qhia tseem ceeb los sib txawv cov neeg muab khoom bovine gelatin zoo heev los ntawm cov neeg ib txwm muaj. Kev tsim cov bovine gelatin ib txwm muaj feem ntau siv cov txheej txheem hydrolysis acid lossis alkali, uas muaj qhov tsis zoo ntawm lub voj voog tsim khoom ntev (20-30 hnub), kev faib tawm qhov hnyav molecular dav ntawm cov khoom, thiab kev ua qias tuaj ib puag ncig loj. Hauv kev sib piv, cov txheej txheem enzymatic hydrolysis niaj hnub muaj qhov zoo pom tseeb, uas tuaj yeem ua kom collagen zoo hauv qab cov xwm txheej tsis hnyav, nrog rau lub voj voog tsim khoom luv dua li 14 teev. Cov bovine gelatin npaj muaj qhov hnyav molecular nqaim dua, lub zog gel siab dua (≥250 Bloom) thiab viscosity, thiab kev ua haujlwm zoo dua ntawm cov khoom. Tib lub sijhawm, cov txheej txheem enzymatic hydrolysis tuaj yeem txo cov pa phem los ntawm 30% -50%, uas yog nyob rau hauv kab nrog lub ntiaj teb sib txawv ntawm kev txhim kho ntsuab thiab qis-carbon. Ib tus neeg muag khoom gelatin nyuj uas ntseeg tau yuav tsum siv cov txheej txheem tsim khoom siab heev thiab nruab nrog cov khoom siv tsim khoom zoo, suav nrog cov kev sib txuas tseem ceeb xws li cov khoom siv raw degreasing, tshem tawm cov khoom tsis huv, rho tawm collagen, ntxuav, pauv ion (kom tshem tawm cov hlau hnyav thiab lwm yam khoom tsis huv), nqus tsev vacuum, thiab ziab tshuaj tsuag. Hauv qhov txuas sterilization, yuav tsum siv cov thev naus laus zis kub siab tam sim ntawd (saum toj no 138 ℃ rau ntau tshaj 4 vib nas this) kom ntseeg tau tias muaj kev huv thiab kev nyab xeeb ntawm cov khoom thaum khaws cov khoom ua haujlwm ntawm gelatin. Tsis tas li ntawd, muaj cov kab ntau lawm uas tuaj yeem hloov kho cov khoom gelatin nrog cov lus qhia sib txawv (xws li cov zog gel sib txawv, viscosities, thiab qhov loj me me) raws li cov neeg siv khoom xav tau qhia txog tus neeg muag khoom lub peev xwm tshawb fawb thiab kev txhim kho thev naus laus zis muaj zog thiab kev hloov pauv hauv kev lag luam.

3. Xaus lus

Hauv kev xaus lus, tus neeg muag khoom gelatin nyuj txhim khu kev qha yuav tsum muaj lub kaw lus tswj xyuas zoo thiab ua tiav thiab cov thev naus laus zis tsim khoom siab heev thiab zoo rau ib puag ncig. Lub kaw lus tswj xyuas zoo ua kom muaj kev nyab xeeb thiab ruaj khov ntawm cov khoom los ntawm qhov chaw thiab tag nrho cov txheej txheem, thaum cov thev naus laus zis tsim khoom siab heev muab kev lees paub rau kev ua tau zoo heev thiab kev tsim khoom ntsuab ntawm cov khoom. Lanpu Gelatin, ua tus kws tshaj lijcov chaw tsim khoom noj gelatin thiab chaw tsim tshuaj gelatin, yeej ib txwm ua raws li cov qauv zoo thoob ntiaj teb hauv tag nrho cov txheej txheem ntawm kev xaiv cov khoom siv raw, kev tsim khoom, thiab kev tshuaj xyuas. Nws siv cov thev naus laus zis enzymatic hydrolysis ntau lawm, tsim kom muaj kev tswj hwm zoo tiav los ntawm ntau lub koom haum muaj cai, thiab siv cov txheej txheem tswj hwm nruj hauv txhua qhov txuas. Nrog cov khoom zoo ruaj khov thiab lub zog zoo heev, Lanpu Gelatin tau dhau los ua tus tsim khoom bovine gelatin ntseeg siab hauv kev lag luam, thiab tuaj yeem muab cov khoom zoo thiab cov kev pabcuam tshaj lij rau cov neeg siv khoom hauv zaub mov, tshuaj, thiab lwm yam teb.